Modeling Heterogeneous Mediation Effects in Survival Analysis via an Interpretable M-Learner Framework

! Biometrics 59,$1 – 25 $ DOI:$10.1111/j .1541 - 0420.2005.00454.x ! December$2006 ! Modeling)Heter ogeneous)Mediation)Effects)in)Survi val)Anal y sis)via)an ! Interpr etable)M - Learner)Fr amew ork ! Xingyu'Li 1 ,'Qing'Liu 2 ,'Xu n'Jiang 2 ,'Hong'Am y'Xia 2 ,'Brian'P .'Hobbs 3 ,'P eng'W ei 1 ∗ ! 1. Department$of$ Biostatisti cs,$The$University$of$T exas$MD$Anderson$Cancer$Ce nter , ! Houston,$TX,$7 7030,$USA. ! 2. Center$for$Design$and$Analysis,$Amgen,$Thousand$Oaks,$CA, $91320,$USA. ! 3. Te l p e r i a n $ I n c , $ T X , $ 7 8 7 3 8 , $ U S A . ! * email:' PW ei2@mdanderson.org ! Summary: Mediati on) ana lysis) is) a ) usefu l) tool ) to) evaluate) s urrogate) endpo ints) in) clini cal) t rials .) W e) propose) a)n ov el) method, ) the)M - surviv al)learner , ) for)estimating) heterogeneous)i ndirect)treatment) effects)i n) the) presence)of) censored) outcomes.)The) proposed) approach) enables) the) identi=?=! @ 11/! '+/! A),6! B/-$+$%.)'.$1+! C@A BD! (%.'*3$%#(/! .#(! 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