Quantitative Biology / Q-Bio.QM

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Benchmarking Preprocessing and Integration Methods in Single-Cell Genomics

Benchmarking Preprocessing and Integration Methods in Single-Cell Genomics

๋ณธ ๋…ผ๋ฌธ์€ ๋‹จ์ผ์„ธํฌ ๋‹ค์ค‘๋ชจ๋‹ฌ ๋ฐ์ดํ„ฐ ๋ถ„์„ ํŒŒ์ดํ”„๋ผ์ธ์˜ ํ•ต์‹ฌ ๋‹จ๊ณ„์ธ ์ •๊ทœํ™”, ํ†ตํ•ฉ, ์ฐจ์› ์ถ•์†Œ๋ฅผ ์ฒด๊ณ„์ ์œผ๋กœ ๋น„๊ตํ•จ์œผ๋กœ์จ ํ˜„์žฌ ์‚ฌ์šฉ๋˜๋Š” ๋ฐฉ๋ฒ•๋“ค์˜ ์‹ค์ œ ์ ์šฉ ๊ฐ€๋Šฅ์„ฑ์„ ํ‰๊ฐ€ํ•œ๋‹ค. ๋จผ์ € ์ •๊ทœํ™” ๋‹จ๊ณ„์—์„œ๋Š” ์ด 7๊ฐ€์ง€ ๋ฐฉ๋ฒ•์„ ์‹œํ—˜ํ–ˆ๋Š”๋ฐ, ์ด๋Š” ์ „ํ†ต์ ์ธ ๋กœ๊ทธ ๋ณ€ํ™˜, SCTransform, CPM, TPM ๋“ฑ๋ถ€ํ„ฐ ์ตœ์‹ ์˜ ๋ฒ ์ด์ง€์•ˆ ๊ธฐ๋ฐ˜ ์ •๊ทœํ™”๊นŒ์ง€ ํฌ๊ด„ํ•œ๋‹ค. ์ •๊ทœํ™”๋Š” ๊ฐ ์„ธํฌ์˜ ๊ธฐ์ˆ ์  ๋ณ€๋™์„ฑ์„ ์ตœ์†Œํ™”ํ•˜๊ณ , ์„œ๋กœ ๋‹ค๋ฅธ ๋ชจ๋‹ฌ๋ฆฌํ‹ฐ ๊ฐ„์˜ ์Šค์ผ€์ผ ์ฐจ์ด๋ฅผ ์กฐ์ •ํ•˜๋Š” ๋ฐ ํ•„์ˆ˜์ ์ด๋ฉฐ, ๋…ผ๋ฌธ์€ ์ •๊ทœํ™” ์„ ํƒ์ด ํ†ตํ•ฉ ๊ฒฐ๊ณผ์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ์„ ์ •๋Ÿ‰์ ์œผ๋กœ ์ œ์‹œํ•œ๋‹ค. ํ†ตํ•ฉ ๋‹จ๊ณ„์—์„œ

Quantitative Biology
On drug transport after intravenous administration

On drug transport after intravenous administration

๋ณธ ๋…ผ๋ฌธ์€ ์•ฝ๋ฌผ ๋‹จ๋ฐฑ์งˆ ๊ฒฐํ•ฉ์˜ ์—ญ๋™์„ฑ๊ณผ ์ด๋ฅผ ๊ธฐ๋ฐ˜์œผ๋กœ ํ•œ ์ˆ˜ํ•™์  ๋ชจ๋ธ๋ง ์ ‘๊ทผ๋ฒ•์— ๋Œ€ํ•ด ์‹ฌ๋„ ์žˆ๊ฒŒ ๋‹ค๋ฃฌ๋‹ค. ์ฃผ์š” ๋‚ด์šฉ์€ ๋‹ค์Œ๊ณผ ๊ฐ™๋‹ค: 1. ์•ฝ๋ฌผ ๋‹จ๋ฐฑ์งˆ ๊ฒฐํ•ฉ์˜ ์ •์˜์™€ ์—ญํ•  : ์•ฝ๋ฌผ ๋‹จ๋ฐฑ์งˆ ๊ฒฐํ•ฉ์€ ๋‹จ๋ฐฑ์งˆ๊ณผ ์•ฝ๋ฌผ ๋ถ„์ž ๊ฐ„์˜ ์ผ์‹œ์ ์ธ ๊ฒฐํ•ฉ์œผ๋กœ, ์ด๋Š” ์งˆ๋Ÿ‰ ์ž‘์šฉ ๋ฒ•์น™์— ๋”ฐ๋ผ ๋ฐ€๋ฆฌ์ดˆ ๋‹จ์œ„๋กœ ์ง„ํ–‰๋œ๋‹ค. ์‹คํ—˜์‹ค ํ™˜๊ฒฝ์—์„œ ๋น„๊ฒฐํ•ฉ๋œ ์•ฝ๋ฌผ ๋ถ„์ž๋Š” ์ž์œ  ์•ฝ๋ฌผ ํ˜ˆ์ค‘ ๋†๋„์™€ ์ด ํ˜ˆ์ค‘ ์•ฝ๋ฌผ ๋†๋„์˜ ๋น„์œจ์„ ํ†ตํ•ด ๊ณ„์‚ฐ๋˜๋ฉฐ, ์ด๋Š” ์ƒˆ๋กœ์šด ์•ฝ๋ฌผ ์„ค๊ณ„ ์‹œ ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•œ๋‹ค. 2. ์ž์œ  ์•ฝ๋ฌผ ๊ฐ€์„ค์— ๋Œ€ํ•œ ์˜๋ฌธ ์ œ๊ธฐ : ์Šค๋ฏธ์Šค ์—ฐ๊ตฌํŒ€์€ '์ž์œ  ์•ฝ๋ฌผ ๊ฐ€์„ค'์— ๋Œ€ํ•ด ์˜๋ฌธ์„

Quantitative Biology
On inconsistencies in passive pharmacokinetics

On inconsistencies in passive pharmacokinetics

๋ณธ ๋…ผ๋ฌธ์€ ์ˆ˜๋™ ์•ฝ๋ฌผ ๋™๋ ฅํ•™์—์„œ ์ผ๊ด€์„ฑ ์—†๋Š” ๊ฒฐ๊ณผ์˜ ์›์ธ์„ ํƒ์ƒ‰ํ•˜๋Š”๋ฐ ์ดˆ์ ์„ ๋งž์ถ”๊ณ  ์žˆ๋‹ค. ์ €์ž๋“ค์€ ์ด๋Ÿฌํ•œ ๋ถˆ์ผ์น˜๊ฐ€ ์ ์ ˆํ•œ ์ง„ํ™” ๋ฐฉ์ •์‹์˜ ๋ถ€์žฌ๋กœ ์ธํ•ด ๋ฐœ์ƒํ•  ๊ฐ€๋Šฅ์„ฑ์ด ๋†’๋‹ค๊ณ  ์ฃผ์žฅํ•œ๋‹ค. ์ด๋Š” ์•ฝ๋ฌผ ๋™๋ ฅํ•™ ์—ฐ๊ตฌ์—์„œ ์ค‘์š”ํ•œ ๋ฌธ์ œ๋ฅผ ์ œ๊ธฐํ•˜๋ฉฐ, ํŠนํžˆ ์‹คํ—˜ ๊ฒฐ๊ณผ์˜ ์ผ๊ด€์„ฑ๊ณผ ์˜ˆ์ธก๋ ฅ์„ ํ–ฅ์ƒ์‹œํ‚ค๋Š” ๋ฐ ์žˆ์–ด ํ•ต์‹ฌ์ ์ธ ์—ญํ• ์„ ํ•œ๋‹ค. ๋…ผ๋ฌธ์€ ํ•œ ๊ฐœ์‹ค ๋ชจ๋ธ์„ ์‚ฌ์šฉํ•˜์—ฌ ์ด๋Ÿฌํ•œ ๋ถˆ์ผ์น˜๋ฅผ ์„ค๋ช…ํ•œ๋‹ค. ์ด ๋ชจ๋ธ์€ ์•ฝ๋ฌผ์ด ์‹œ๊ฐ„์— ๋”ฐ๋ผ ์–ด๋–ป๊ฒŒ ๋ณ€ํ™”ํ•˜๋Š”์ง€ ๋‚˜ํƒ€๋‚ด๋Š” ๋ฐฉ์ •์‹์„ ํ†ตํ•ด ์•ฝ๋ฌผ ๋™๋ ฅํ•™์˜ ๊ธฐ๋ณธ ์›๋ฆฌ๋ฅผ ๋ณด์—ฌ์ค€๋‹ค. ํŠนํžˆ, $C(t)$๋Š” ์‹œ๊ฐ„ $t$์—์„œ์˜ ์•ฝ๋ฌผ ๋†๋„๋ฅผ ๋‚˜

Quantitative Biology
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Multiscale Modelling: A Mobile Membrane Approach

: ๋ณธ ๋…ผ๋ฌธ์€ ์ƒ๋ฌผํ•™์  ๊ณผ์ • ์—ฐ๊ตฌ์— ์žˆ์–ด ๋‹ค์ค‘ ๊ทœ๋ชจ ๋ชจ๋ธ๋ง์˜ ์ค‘์š”์„ฑ๊ณผ ๊ทธ ๊ตฌํ˜„ ๋ฐฉ๋ฒ•์„ ํƒ๊ตฌํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ํŠนํžˆ, ์ด๋™์„ฑ ๋ง‰ ์‹œ์Šคํ…œ์ด ์ด๋Ÿฌํ•œ ๋ชจ๋ธ๋ง ์ ‘๊ทผ๋ฒ•์—์„œ ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•˜๋Š”๋ฐ ์ดˆ์ ์„ ๋งž์ถ”๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. 1. ๋‹ค์ค‘ ๊ทœ๋ชจ ๋ชจ๋ธ๋ง์˜ ํ•„์š”์„ฑ ์ž์—ฐ ํ˜„์ƒ์€ ๋‹ค์–‘ํ•œ ๊ณต๊ฐ„์  ๋ฐ ์‹œ๊ฐ„์  ๊ทœ๋ชจ์—์„œ ์ƒํ˜ธ์ž‘์šฉํ•˜๋ฉฐ ๋ฐœ์ƒํ•ฉ๋‹ˆ๋‹ค. ๋”ฐ๋ผ์„œ, ์ด๋ฅผ ํšจ๊ณผ์ ์œผ๋กœ ์—ฐ๊ตฌํ•˜๋ ค๋ฉด ๋‹ค์ค‘ ๊ทœ๋ชจ ๋ชจ๋ธ๋ง์ด ํ•„์ˆ˜์ ์ž…๋‹ˆ๋‹ค. ๋ณต์žก ์ž๋™๋ฌธ(CxA)์€ ์ด๋Ÿฌํ•œ ๋‹ค์ค‘ ๊ทœ๋ชจ ์ ‘๊ทผ๋ฒ•์„ ๊ตฌํ˜„ํ•˜๋Š” ๋ฐ ๊ฐ€์žฅ ์ ํ•ฉํ•œ ์‹œ์Šคํ…œ์œผ๋กœ ๊ฐ„์ฃผ๋ฉ๋‹ˆ๋‹ค. 2. ์ด๋™์„ฑ ๋ง‰ ์‹œ์Šคํ…œ์˜ ํ™œ์šฉ ์ด๋™์„ฑ ๋ง‰ ์‹œ์Šคํ…œ์€ ์ƒ๋ฌผํ•™์  ์›€

Formal Languages Quantitative Biology Model Computer Science Emerging Technologies
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Harmonic analysis of spherical sampling in diffusion MRI

๋ณธ ๋…ผ๋ฌธ์€ ํ™•์‚ฐ MRI์—์„œ ๋‹ค์ค‘ ์…ธ ๊ตฌํ˜• ์ƒ˜ํ”Œ๋ง์˜ ํšจ์œจ์„ฑ์„ ์ด๋ก ์ ์œผ๋กœ ๋ถ„์„ํ•˜๊ณ , ์ด๋ฅผ ํ†ตํ•ด HYDI์™€ ์œ ์‚ฌํ•œ ์ ‘๊ทผ ๋ฐฉ์‹์— ๋Œ€ํ•œ ์ดํ•ด๋ฅผ ์ฆ์ง„์‹œํ‚ค๋ฉฐ ํ–ฅํ›„ ์ตœ์ ํ™” ์ „๋žต์„ ์ œ์‹œํ•˜๋Š” ๊ฒƒ์„ ๋ชฉํ‘œ๋กœ ํ•œ๋‹ค. ์—ฐ๊ตฌ๋Š” ํ™•์‚ฐ MRI์—์„œ ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•˜๋Š” ๋ฐฉํ–ฅ ๋ถ„ํฌ ํ•จ์ˆ˜(ODF)์˜ ๊ณ„์‚ฐ ๋ฐฉ๋ฒ•๊ณผ ๊ทธ ๊ณผ์ •์—์„œ ๋ฐœ์ƒํ•  ์ˆ˜ ์žˆ๋Š” ๋ฌธ์ œ์ ๋“ค์„ ์ง‘์ค‘์ ์œผ๋กœ ๋‹ค๋ฃฌ๋‹ค. 1. ODF์™€ ๊ตฌ๋ฉด ์กฐํ™” ๋ณ€ํ™˜(SH) ODF๋Š” ํ™•์‚ฐ ์‹ ํ˜ธ๋ฅผ ๋ฐฉํ–ฅ๋ณ„๋กœ ๋ถ„์„ํ•˜์—ฌ ๋‡Œ ๋‚ด ๋ฏธ์„ธ๊ตฌ์กฐ์˜ ๋ฐฉํ–ฅ์„ฑ์„ ํŒŒ์•…ํ•˜๋Š” ๋ฐ ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•œ๋‹ค. ์ด ๋…ผ๋ฌธ์—์„œ๋Š” ODF๋ฅผ ๊ณ„์‚ฐํ•˜๊ธฐ ์œ„ํ•ด ๊ตฌ๋ฉด ์กฐํ™” ๋ณ€ํ™˜(SH)์„ ์‚ฌ

Analysis Quantitative Biology Physics

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