Quantitative Biology / Q-Bio.BM

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Comment on 'Length-dependent translation of messenger RNA by ribosomes'

Comment on 'Length-dependent translation of messenger RNA by ribosomes'

1. ๋…ผ๋ฌธ์˜ ๋ฐฐ๊ฒฝ๊ณผ ๋ชฉ์  Valleriani ์™ธ ์—ฐ๊ตฌ์ง„์€ ๋ฉ”์‹ ์ € RNA(mRNA)์˜ ๊ธธ์ด์— ๋”ฐ๋ฅธ ๋‹จ๋ฐฑ์งˆ ํ•ฉ์„ฑ ์†๋„๋ฅผ ๋ชจ๋ธ๋งํ•˜๋Š” ๊ฐ„๋‹จํ•œ ๋ฐฉ๋ฒ•์„ ์ œ์‹œํ–ˆ์Šต๋‹ˆ๋‹ค. ์ด ๋ชจ๋ธ์—์„œ mRNA ๋ถ„ํ•ด ๊ณผ์ •์€ ฯ‰r์ด๋ผ๋Š” ์ƒ์ˆ˜๋กœ ํ‘œํ˜„๋˜๋ฉฐ, ๋ฆฌ๋ณด์†œ์— ์˜ํ•œ ๋ฒˆ์—ญ ์†๋„๋Š” ฯ‰tl๋กœ ํ‘œ๊ธฐ๋ฉ๋‹ˆ๋‹ค. ๋‹จ๋ฐฑ์งˆ์˜ ๋ถ„ํ•ด ์†๋„๋Š” ฯ‰p๋กœ ๋‚˜ํƒ€๋‚ด์–ด์ ธ ์žˆ์œผ๋ฉฐ, ์ด๋“ค ๊ฐ„์˜ ๋น„์œจ r ฯ‰tl/ฯ‰p๊ฐ€ mRNA ๊ธธ์ด์— ๋”ฐ๋ผ ์–ด๋–ป๊ฒŒ ๋ณ€ํ•˜๋Š”์ง€ ๋ถ„์„ํ•ฉ๋‹ˆ๋‹ค. 2. ๋ฒˆ์—ญ ๋น„์œจ r์„ ์–ป๊ธฐ ์œ„ํ•œ ์„ธ ๊ฐ€์ง€ ๋ฐฉ๋ฒ• ๋ณธ ๋…ผํ‰์—์„œ๋Š” Valleriani ์—ฐ๊ตฌ์ง„์˜ ๋ชจ๋ธ์„ ํ™•์žฅํ•˜์—ฌ, ๋ฒˆ์—ญ ๋น„์œจ r์„ ์–ป๋Š” ์„ธ ๊ฐ€์ง€

Quantitative Biology Physics
Nucleated polymerisation in the presence of pre-formed seed filaments

Nucleated polymerisation in the presence of pre-formed seed filaments

: ๋ณธ ๋…ผ๋ฌธ์€ ์˜ค์˜ค์‚ฌ์™€(Oosawa)์˜ ๊ณ ์ „์ ์ธ ๋ˆ„ํด๋ ˆ์ดํ‹ฐ๋“œ ์ค‘ํ•ฉ ์ด๋ก ์„ ํ™•์žฅํ•˜์—ฌ, ์ƒ๋ฌผ ํ•„๋ผ๋ฉ˜ํŠธ ์„ฑ์žฅ์„ ์„ค๋ช…ํ•˜๋Š” ์ƒˆ๋กœ์šด ๊ด€์ ์„ ์ œ์‹œํ•ฉ๋‹ˆ๋‹ค. ํŠนํžˆ ์ฃผ๋œ ๊ด€์‹ฌ์‚ฌ๋Š” ์‚ฌ์ „ ํ˜•์„ฑ๋œ ์”จ์•— ๋ฌผ์งˆ์ด ์กด์žฌํ•˜๋Š” ์‹œ์Šคํ…œ์—์„œ์˜ ์ค‘ํ•ฉ ๊ณผ์ •์ž…๋‹ˆ๋‹ค. 1. ๋ˆ„ํด๋ ˆ์ดํ‹ฐ๋“œ ์ค‘ํ•ฉ ์ด๋ก ์˜ ๋ฐฐ๊ฒฝ ์˜ค์˜ค์‚ฌ์™€๋Š” 1960๋…„๋Œ€์— ์ƒ๋ฌผ ํ•„๋ผ๋ฉ˜ํŠธ ์„ฑ์žฅ์„ ์„ค๋ช…ํ•˜๊ธฐ ์œ„ํ•ด ๋ˆ„ํด๋ ˆ์ดํ‹ฐ๋“œ ์ค‘ํ•ฉ ์ด๋ก ์„ ๊ฐœ๋ฐœํ–ˆ์Šต๋‹ˆ๋‹ค. ์ด ์ด๋ก ์€ ์ฃผ๋œ ๋ˆ„ํด๋ ˆ์ด์…˜๊ณผ ๊ธธ์–ด์ง, ๊ทธ๋ฆฌ๊ณ  ๋ถ„ํ•ด ๊ณผ์ •์„ ๊ณ ๋ คํ•˜์—ฌ ์•กํ‹ด๊ณผ ํŠœ๋ถˆ๋ฆฐ ๊ฐ™์€ ๋‹จ๋ฐฑ์งˆ์˜ ์ค‘ํ•ฉ์„ ์„ค๋ช…ํ•ฉ๋‹ˆ๋‹ค. ์ดํ›„ ์—ํŠผ๊ณผ ํŽ˜๋ก ๋„ค๋Š” ์ด ์ด๋ก ์„ ํ™•์žฅํ•˜์—ฌ ์ฐจ์„ธ๋Œ€ ๋ˆ„ํด๋ ˆ์ด์…˜ ๊ฒฝ

Quantitative Biology Physics Condensed Matter
Rigidity analysis of HIV-1 protease

Rigidity analysis of HIV-1 protease

๋ณธ ๋…ผ๋ฌธ์€ HIV 1 ํ”„๋กœํ…Œ์•„์ œ์˜ ๊ตฌ์กฐ ๊ฐ•๋„๋ฅผ ๋ถ„์„ํ•˜๋Š” ๋ฐ ์ดˆ์ ์„ ๋งž์ถ”๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. HIV 1 ํ”„๋กœํ…Œ์•„์ œ๋Š” AIDS ๋ฐ”์ด๋Ÿฌ์Šค์˜ ๋ณต์ œ ๊ณผ์ •์—์„œ ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•˜๋Š” ํšจ์†Œ๋กœ, ์ด ํšจ์†Œ์˜ ๊ตฌ์กฐ์™€ ๊ธฐ๋Šฅ์— ๋Œ€ํ•œ ์ดํ•ด๋Š” ํ•ญ๋ฐ”์ด๋Ÿฌ์Šค ์น˜๋ฃŒ๋ฒ• ๊ฐœ๋ฐœ์— ์žˆ์–ด ํ•ต์‹ฌ์ ์ธ ์š”์†Œ์ž…๋‹ˆ๋‹ค. ๋ณธ ์—ฐ๊ตฌ์—์„œ๋Š” FIRST(Flexible and Rigid Clusters) ์†Œํ”„ํŠธ์›จ์–ด๋ฅผ ํ™œ์šฉํ•˜์—ฌ HIV 1 ํ”„๋กœํ…Œ์•„์ œ์˜ ๊ฐ•๋„ ๋ถ„์„์„ ์ˆ˜ํ–‰ํ–ˆ์Šต๋‹ˆ๋‹ค. FIRST ์†Œํ”„ํŠธ์›จ์–ด๋Š” ํŽ˜๋ธ” ๊ฒŒ์ž„ ์•Œ๊ณ ๋ฆฌ์ฆ˜์„ ๊ธฐ๋ฐ˜์œผ๋กœ ํ•˜๋ฉฐ, ๋‹จ๋ฐฑ์งˆ ๋‚ด์—์„œ ๊ฒฐํ•ฉ์— ์˜ํ•œ ์ œ์•ฝ ์กฐ๊ฑด๊ณผ ์›์ž ์ž์œ ๋„๋ฅผ ๋งค์นญ์‹œ์ผœ ๊ฐ•๊ณ ํ•œ

Analysis Quantitative Biology

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